1O37

Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors

Summary for 1O37
Related1C5R
DescriptorBETA-TRYPSIN, CALCIUM ION, 5-(2-AMINOETHYL)-3-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL}-1,1'-BIPHENYL-2-OLATE, ... (4 entities in total)
Functional Keywordsserine protease, short hydrogen bond, inhibition mechanism, shift of pka, trypsin, thrombin, urokinase, factor xa, hydrolase
Biological sourceBos taurus (cattle)
Cellular locationSecreted, extracellular space: P00760
Total number of polymer chains1
Total formula weight23736.81
Authors
Primary citationAllen, D.,Breitenbucher, J.G.,Elrod, K.,Hui, H.C.,Janc, J.W.,Katz, B.A.,Kolesnikov, A.,Luong, C.,Mackman, R.L.,Sendzik, M.,Shrader, W.D.,Spencer, J.R.,Sprengeler, P.A.,Tai, V.W.,Verner, E.
Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors.
J.Mol.Biol., 329:93-120, 2003
PubMed: 12742021
DOI: 110.1016/S0022-2836(03)00399-1
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.45 Å)
Structure validation
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178938

PDB entries from 2021-06-16