1O2Z

Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors

Summary for 1O2Z
Related1C5R
DescriptorBETA-TRYPSIN, CALCIUM ION, 2-(5-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL}-2'-METHOXY-6-OXIDO-1,1'-BIPHENYL-3-YL)SUCCINATE, ... (4 entities in total)
Functional Keywordsserine protease, short hydrogen bond, inhibition mechanism, shift of pka, trypsin, thrombin, urokinase, factor xa, hydrolase
Biological sourceBos taurus (cattle)
Cellular locationSecreted, extracellular space: P00760
Total number of polymer chains1
Total formula weight23836.82
Authors
Primary citationAllen, D.,Breitenbucher, J.G.,Elrod, K.,Hui, H.C.,Janc, J.W.,Katz, B.A.,Kolesnikov, A.,Luong, C.,Mackman, R.L.,Sendzik, M.,Shrader, W.D.,Spencer, J.R.,Sprengeler, P.A.,Tai, V.W.,Verner, E.
Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors.
J.Mol.Biol., 329:93-120, 2003
PubMed: 12742021
DOI: 110.1016/S0022-2836(03)00399-1
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.65 Å)
Structure validation
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PDB entries from 2021-06-16