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1C5T

STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR

Summary for 1C5T
Entry DOI10.2210/pdb1c5t/pdb
DescriptorPROTEIN (TRYPSIN), CALCIUM ION, THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDINE, ... (4 entities in total)
Functional Keywordsselective, s1 site inhibitor, structure-based drug design, urokinase, trypsin, thrombin, hydrolase
Biological sourceBos taurus (cattle)
Cellular locationSecreted, extracellular space: P00760
Total number of polymer chains1
Total formula weight23542.60
Authors
Katz, B.A.,Mackman, R.,Luong, C.,Radika, K.,Martelli, A.,Sprengeler, P.A.,Wang, J.,Chan, H.,Wong, L. (deposition date: 1999-12-22, release date: 2000-12-22, Last modification date: 2023-12-27)
Primary citationKatz, B.A.,Mackman, R.,Luong, C.,Radika, K.,Martelli, A.,Sprengeler, P.A.,Wang, J.,Chan, H.,Wong, L.
Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7:299-312, 2000
Cited by
PubMed: 10779411
DOI: 10.1016/S1074-5521(00)00104-6
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.37 Å)
Structure validation

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