1GI4

A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE

Summary for 1GI4
Related1C5R
DescriptorBETA-TRYPSIN, CALCIUM ION, ZINC ION, ... (6 entities in total)
Functional Keywordsthree-centered, very short hydrogen bond, oxyanion hole water, shift of pka of his57, structure-based drug design, specificity, urokinase, trypsin, thrombin, zn+2-mediated inhibition, hydrolase
Biological sourceBos taurus (cattle)
Cellular locationSecreted, extracellular space: P00760
Total number of polymer chains1
Total formula weight23779.12
Authors
Katz, B.A.,Elrod, K.,Luong, C.,Rice, M.,Mackman, R.L.,Sprengeler, P.A.,Spencer, J.,Hatayte, J.,Janc, J.,Link, J.,Litvak, J.,Rai, R.,Rice, K.,Sideris, S.,Verner, E.,Young, W. (deposition date: 2001-01-22, release date: 2002-01-22, Last modification date: 2017-10-04)
Primary citationElrod, K.,Hataye, J.,Janc, J.,Katz, B.A.,Link, J.,Litvak, J.,Luong, C.,Mackman, R.L.,Rai, R.,Rice, K.,Rice, M.J.,Sideris, S.,Spencer, J.,Sprengeler, P.A.,Verner, E.,Young, W.
A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
J.Mol.Biol., 307:1451-1486, 2001
PubMed: 11292354
DOI: 110.1006/jmbi.2001.4516
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.37 Å)
Structure validation
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PDB entries from 2021-06-16