1C5R
STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Summary for 1C5R
Entry DOI | 10.2210/pdb1c5r/pdb |
Descriptor | PROTEIN (TRYPSIN), CITRATE ANION, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | selective, s1 site inhibitor, structure-based drug design, urokinase, trypsin, thrombin, hydrolase |
Biological source | Bos taurus (cattle) |
Cellular location | Secreted, extracellular space: P00760 |
Total number of polymer chains | 1 |
Total formula weight | 24048.73 |
Authors | Katz, B.A.,Mackman, R.,Luong, C.,Radika, K.,Martelli, A.,Sprengeler, P.A.,Wang, J.,Chan, H.,Wong, L. (deposition date: 1999-12-22, release date: 2000-12-22, Last modification date: 2023-12-27) |
Primary citation | Katz, B.A.,Mackman, R.,Luong, C.,Radika, K.,Martelli, A.,Sprengeler, P.A.,Wang, J.,Chan, H.,Wong, L. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem.Biol., 7:299-312, 2000 Cited by PubMed: 10779411DOI: 10.1016/S1074-5521(00)00104-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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