1NC6

Potent, small molecule inhibitors of human mast cell tryptase. Anti-asthmatic action of a dipeptide-based transition state analogue containing benzothiazole ketone

Summary for 1NC6
DescriptorTrypsinogen, CALCIUM ION, SULFATE ION, ... (5 entities in total)
Functional Keywordsprotein-inhibitor complex, hydrolase
Biological sourceBos taurus (cattle)
Cellular locationSecreted, extracellular space: P00760
Total number of polymer chains1
Total formula weight23906.95
Authors
Primary citationAbraham, W.M.,Almond Jr., H.R.,Andrade-Gordon, P.,Chattopadhyay, D.,Corcoran, T.W.,Costanzo, M.J.,De Garavilla, L.,Kauffman, J.A.,Maryanoff, B.E.,Recacha, R.,Yabut, S.C.
Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone.
J.Med.Chem., 46:3865-3876, 2003
PubMed: 12930148
DOI: 110.1021/jm030050p
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation
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PDB entries from 2021-06-16