1NC6

Potent, small molecule inhibitors of human mast cell tryptase. Anti-asthmatic action of a dipeptide-based transition state analogue containing benzothiazole ketone

Summary for 1NC6

Entry DOI	10.2210/pdb1nc6/pdb
Descriptor	Trypsinogen, CALCIUM ION, SULFATE ION, ... (5 entities in total)
Functional Keywords	protein-inhibitor complex, hydrolase
Biological source	Bos taurus (cattle)
Cellular location	Secreted, extracellular space: P00760
Total number of polymer chains	1
Total formula weight	23906.95
Authors	Costanzo, M.J.,Yabut, S.C.,Almond Jr., H.R.,Andrade-Gordon, P.,Corcoran, T.W.,de Garavilla, L.,Kauffman, J.A.,Abraham, W.M.,Recacha, R.,Chattopadhyay, D.,Maryanoff, B.E. (deposition date: 2002-12-04, release date: 2003-09-23, Last modification date: 2017-10-11)
Primary citation	Costanzo, M.J.,Yabut, S.C.,Almond Jr., H.R.,Andrade-Gordon, P.,Corcoran, T.W.,De Garavilla, L.,Kauffman, J.A.,Abraham, W.M.,Recacha, R.,Chattopadhyay, D.,Maryanoff, B.E. Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone. J.Med.Chem., 46:3865-3876, 2003 Cited by PubMed: 12930148 DOI: 10.1021/jm030050p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation