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1O2L

Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors

Summary for 1O2L
Entry DOI10.2210/pdb1o2l/pdb
Related1C5R
DescriptorBETA-TRYPSIN, CALCIUM ION, 3-{5-[AMINO(IMINIO)METHYL]-6-CHLORO-1H-BENZIMIDAZOL-2-YL}-1,1'-BIPHENYL-2-OLATE, ... (4 entities in total)
Functional Keywordsserine protease, short hydrogen bond, inhibition mechanism, shift of pka, trypsin, thrombin, urokinase, factor xa, hydrolase
Biological sourceBos taurus (cattle)
Cellular locationSecreted, extracellular space: P00760
Total number of polymer chains1
Total formula weight23727.18
Authors
Primary citationKatz, B.A.,Elrod, K.,Verner, E.,Mackman, R.L.,Luong, C.,Shrader, W.D.,Sendzik, M.,Spencer, J.R.,Sprengeler, P.A.,Kolesnikov, A.,Tai, V.W.-F.,Hui, H.C.,Breitenbucher, J.G.,Allen, D.,Janc, J.W.
Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
J.Mol.Biol., 329:93-120, 2003
Cited by
PubMed: 12742021
DOI: 10.1016/S0022-2836(03)00399-1
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.68 Å)
Structure validation

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