1TYN

ATOMIC STRUCTURE OF THE TRYPSIN-CYCLOTHEONAMIDE A COMPLEX: LESSONS FOR THE DESIGN OF SERINE PROTEASE INHIBITORS

Summary for 1TYN

DescriptorBETA-TRYPSIN, CYCLOTHEONAMIDE A (3 entities in total)
Functional Keywordshydrolase(serine protease)
Biological sourceBos taurus (cattle)
Cellular locationSecreted, extracellular space P00760
Total number of polymer chains1
Total molecular weight24056.09
Authors
Lee, A.Y.,Hagihara, M.,Karmacharya, R.,Albers, M.W.,Schreiber, S.L.,Clardy, J. (deposition date: 1994-09-19, release date: 1995-01-26, Last modification date: 2011-07-13)
Primary citation
Lee, A.Y.,Hagihara, M.,Karmacharya, R.,Albers, M.W.,Schreiber, S.L.,Clardy, J.
Atomic Structure of the Trypsin-Cyclotheonamide a Complex: Lessons for the Design of Serine Protease Inhibitors
J.Am.Chem.Soc., 115:12619-, 1993
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers50.5%3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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167327
PDB entries from 2020-08-05