Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1AUJ

BOVINE TRYPSIN COMPLEXED TO META-CYANO-BENZYLIC INHIBITOR

Summary for 1AUJ
Entry DOI10.2210/pdb1auj/pdb
DescriptorTRYPSIN, CALCIUM ION, 1-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACID, ... (4 entities in total)
Functional Keywordshydrolase, serine proteinase
Biological sourceBos taurus (cattle)
Cellular locationSecreted, extracellular space: P00760
Total number of polymer chains1
Total formula weight23798.66
Authors
Alexander, R.,Smallwood, A.,Kettner, C. (deposition date: 1997-08-28, release date: 1998-10-14, Last modification date: 2011-07-13)
Primary citationLee, S.L.,Alexander, R.S.,Smallwood, A.,Trievel, R.,Mersinger, L.,Weber, P.C.,Kettner, C.
New inhibitors of thrombin and other trypsin-like proteases: hydrogen bonding of an aromatic cyano group with a backbone amide of the P1 binding site replaces binding of a basic side chain.
Biochemistry, 36:13180-13186, 1997
Cited by
PubMed: 9341205
DOI: 10.1021/bi970912m
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon