1ZZZ

Trypsin inhibitors with rigid tripeptidyl aldehydes

Summary for 1ZZZ

Entry DOI	10.2210/pdb1zzz/pdb
Related	1yyy
Related PRD ID	PRD_000324
Descriptor	TRYPSIN, 2-{(3S)-3-[(benzylsulfonyl)amino]-2-oxopiperidin-1-yl}-N-{(2S)-1-[(3R)-1-carbamimidoylpiperidin-3-yl]-3-oxopropan-2-yl}acetamide, CALCIUM ION, ... (4 entities in total)
Functional Keywords	serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Bos taurus (cattle)
Cellular location	Secreted, extracellular space: P00760
Total number of polymer chains	1
Total formula weight	25286.51
Authors	Krishnan, R.,Zhang, E.,Hakansson, K.,Arni, R.K.,Tulinsky, A.,Lim-Wilby, M.S.L.,Levy, O.E.,Semple, J.E.,Brunck, T.K. (deposition date: 1998-06-02, release date: 1999-06-15, Last modification date: 2023-08-09)
Primary citation	Krishnan, R.,Zhang, E.,Hakansson, K.,Arni, R.K.,Tulinsky, A.,Lim-Wilby, M.S.,Levy, O.E.,Semple, J.E.,Brunck, T.K. Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes. Biochemistry, 37:12094-12103, 1998 Cited by PubMed: 9724521 DOI: 10.1021/bi980840e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation