Structural and thermodynamic consequences of cyclization of peptide ligands for the recruitment site of cyclin A

Summary for 2WMA

Related1H08 1PYE 2VTH 2B53 1V1K 1KE7 1OKV 1H25 1PXK 2WIH 2BHH 2VTA 2UUE 1E1V 1GZ8 1OL2 1H27 1JSV 2WHA 2B52 1KE5 1FIN 2C5O 2C68 2VTT 1P2A 2C4G 2VTQ 1H1Q 1W0X 1PXO 2W05 1KE9 2A0C 1HCK 1JSU 1PXN 2UZE 2VTM 2V0D 1OIQ 1H1R 2IW8 1GIH 1PW2 1HCL 2WHB 2W06 2VTN 1JST 1OIU 1PXM 1B38 1FQ1 1VYW 1H1P 2C69 1URC 1PXI 2C6I 1YKR 2W17 2C5Y 2C6K 2UZD 1WCC 2J9M 1VYZ 2VTI 1JVP 1W98 2WIP 1PKD 1P5E 2VTS 2C5P 2UZN 2B54 1KE6 1PXJ 2UZL 2CCI 2BKZ 2G9X 1Y91 2IW6 1GIJ 1R78 1H0V 2IW9 1W8C 1BUH 2BPM 2BTS 1FVV 1OKW 2A4L 2VTP 2C6T 1FVT 1QMZ 2W1H 2VU3 1OGU 2B55 1PF8 1H1S 2C5V 2JGZ 2BHE 1URW 1OIY 2C6L 2C6O 1F5Q 2VTL 1OL1 2WFY 1H01 2UZB 1OIR 1OI9 2VTJ 2CJM 2WEV 2C5X 2C5N 2C6M 1OIT 1GY3 2V22 2VV9 1DI8 1GII 1E9H 1DM2 2VTO 1H24 2UZO 1H00 2EXM 2CLX 1PXP 2CCH 2BTR 1B39 1AQ1 1H0W 1CKP 1G5S 1PXL 1H28 1KE8 1H26 2VTR 1E1X 1H07 1Y8Y 2WMB
DescriptorCELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, CYCLIC RKLFN-NH2, ... (4 entities in total)
Functional Keywordscell cycle, cell division, anti-oncogene, serine/threonine-protein kinase, phosphorylation, nucleotide-binding, transcription regulation, chromatin regulator, recruitment, transcription, nucleus, mitosis, atp-binding, transferase
Biological sourceHOMO SAPIENS
Cellular locationNucleus P20248
Total number of polymer chains5
Total molecular weight129121.5
Robertson, G.F.,Endicott, J.A.,Noble, M.E.M.,McDonnell, J.M. (deposition date: 2009-06-30, release date: 2010-09-01, Last modification date: 2011-07-13)
Primary citation
Robertson, G.F.,Endicott, J.A.,Noble, M.E.M.,Mcdonnell, J.M.
Structural and Thermodynamic Consequences of Cyclization of Peptide Ligands for the Recruitment Site of Cyclin A
To be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.283194.0%8.0%4.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report