1H1R

Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6086

Summary for 1H1R

Related1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1GZ8 1H00 1H01 1H06 1H07 1H08 1H0U 1H0V 1H0W 1H1P 1H1Q 1H1S 1HCK 1HCL 1JST 1JSU 1JSV 1JVP 1KE5 1KE6 1KE7 1KE8 1KE9 1QMZ
DescriptorCELL DIVISION PROTEIN KINASE 2, CYCLIN A2, 6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINE, ... (4 entities in total)
Functional Keywordskinase, transferase, serine/threonine-protein kinase, atp-binding, cell cycle, cell division, mitosis, phosphorylation
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains4
Total molecular weight128900.12
Authors
Davies, T.G.,Noble, M.E.M.,Endicott, J.A.,Johnson, L.N. (deposition date: 2002-07-21, release date: 2002-09-19, Last modification date: 2019-02-06)
Primary citation
Davies, T.G.,Bentley, J.,Arris, C.E.,Boyle, F.T.,Curtin, N.J.,Endicott, J.A.,Gibson, A.E.,Golding, B.T.,Griffin, R.J.,Hardcastle, I.R.,Jewsbury, P.,Johnson, L.N.,Mesguiche, V.,Newell, D.R.,Noble, M.E.,Tucker, J.A.,Wang, L.,Whitfield, H.J.
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor.
Nat. Struct. Biol., 9:745-749, 2002
PubMed: 12244298 (PDB entries with the same primary citation)
DOI: 10.1038/nsb842
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27422 2.1% 9.0% 18.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution