1JSU

P27(KIP1)/CYCLIN A/CDK2 COMPLEX

Summary for 1JSU

• Entry DOI: 10.2210/pdb1jsu/pdb
• Descriptor: CYCLIN-DEPENDENT KINASE-2, CYCLIN A, P27, ... (5 entities in total)
• Functional Keywords: complex (transferase-cyclin-inhibitor), kinase, cell cycle, cell division, cdk, cyclin, inhibitor, complex (transferase-cyclin-inhibitor) complex, complex (transferase/cyclin/inhibitor)
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P20248 P46527
• Total number of polymer chains: 3
• Total formula weight: 73990.20

Authors

Russo, A.A.,Jeffrey, P.D.,Pavletich, N.P. (deposition date: 1996-07-03, release date: 1997-07-29, Last modification date: 2024-10-16)

Primary citation

Russo, A.A.,Jeffrey, P.D.,Patten, A.K.,Massague, J.,Pavletich, N.P.
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
Nature, 382:325-331, 1996

PubMed Abstract: The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom. p27Kip1 binds the complex as an extended structure interacting with both cyclin A and Cdk2. On cyclin A, it binds in a groove formed by conserved cyclin box residues. On Cdk2, it binds and rearranges the amino-terminal lobe and also inserts into the catalytic cleft, mimicking ATP.

PubMed: 8684460
DOI: 10.1038/382325a0

Experimental method

X-RAY DIFFRACTION (2.3 Å)