1GZ8

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 2-Amino-6-(3'-methyl-2'-oxo)butoxypurine

Summary for 1GZ8

Related1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1HCK 1HCL 1JST 1JSU 1JSV 1JVP 1QMZ
DescriptorCELL DIVISION PROTEIN KINASE 2, 1-[(2-AMINO-6,9-DIHYDRO-1H-PURIN-6-YL)OXY]-3-METHYL-2-BUTANOL (3 entities in total)
Functional Keywordskinase, protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase, serine/threonine-protein kinase, atp-binding, 3d-structure.
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total molecular weight34269.77
Authors
Davies, T.,Endicott, J.,Johnson, L.,Noble, M.,Tucker, J. (deposition date: 2002-05-17, release date: 2003-06-12, Last modification date: 2019-03-06)
Primary citation
Gibson, A.E.,Arris, C.E.,Bentley, J.,Boyle, F.T.,Curtin, N.J.,Davies, T.G.,Endicott, J.A.,Golding, B.T.,Grant, S.,Griffin, R.J.,Jewsbury, P.,Johnson, L.N.,Mesguiche, V.,Newell, D.R.,Noble, M.E.,Tucker, J.A.,Whitfield, H.J.
Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O(6)-Substituted Guanine Derivatives
J.Med.Chem., 45:3381-, 2002
PubMed: 12139449 (PDB entries with the same primary citation)
DOI: 10.1021/JM020056Z
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.19760 3.5% 10.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1gz8
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Molmil generated image of 1gz8
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Molmil generated image of 1gz8
rotated about y axis by 90°