1E1V
HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU2058
Summary for 1E1V
Entry DOI | 10.2210/pdb1e1v/pdb |
Related | 1AQ1 1B38 1B39 1BUH 1CKP 1E1X 1FIN 1HCK 1HCL 1JST 1JSU |
Descriptor | CYCLIN-DEPENDENT PROTEIN KINASE 2, 6-O-CYCLOHEXYLMETHYL GUANINE (3 entities in total) |
Functional Keywords | protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 34249.82 |
Authors | Endicott, J.A.,Noble, M.E.M.,Johnson, L.N. (deposition date: 2000-05-11, release date: 2001-05-10, Last modification date: 2023-12-06) |
Primary citation | Arris, C.E.,Boyle, F.T.,Calvert, A.H.,Curtin, N.J.,Endicott, J.A.,Garman, E.F.,Gibson, A.E.,Golding, B.T.,Grant, S.,Griffin, R.J.,Jewsbury, P.,Johnson, L.N.,Lawrie, A.M.,Newell, D.R.,Noble, M.E.M.,Sausville, E.A.,Schultz, R.,Yu, W. Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles. J.Med.Chem., 43:2797-, 2000 Cited by PubMed: 10956187DOI: 10.1021/JM990628O PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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