1G5S
CRYSTAL STRUCTURE OF HUMAN CYCLIN DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH THE INHIBITOR H717
Summary for 1G5S
Entry DOI | 10.2210/pdb1g5s/pdb |
Descriptor | CELL DIVISION PROTEIN KINASE 2, 2-[TRANS-(4-AMINOCYCLOHEXYL)AMINO]-6-(BENZYL-AMINO)-9-CYCLOPENTYLPURINE (3 entities in total) |
Functional Keywords | protein-inhibitor complex, cell cycle-transferase complex, cell cycle/transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 |
Total number of polymer chains | 1 |
Total formula weight | 34382.03 |
Authors | Dreyer, M.K.,Borcherding, D.R.,Dumont, J.A.,Peet, N.P.,Tsay, J.T.,Wright, P.S.,Bitonti, A.J.,Shen, J.,Kim, S.-H. (deposition date: 2000-11-02, release date: 2001-11-02, Last modification date: 2023-08-09) |
Primary citation | Dreyer, M.K.,Borcherding, D.R.,Dumont, J.A.,Peet, N.P.,Tsay, J.T.,Wright, P.S.,Bitonti, A.J.,Shen, J.,Kim, S.H. Crystal structure of human cyclin-dependent kinase 2 in complex with the adenine-derived inhibitor H717. J.Med.Chem., 44:524-530, 2001 Cited by PubMed: 11170642DOI: 10.1021/jm001043t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
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