1FIN

CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX

Summary for 1FIN

• Entry DOI: 10.2210/pdb1fin/pdb
• Descriptor: CYCLIN-DEPENDENT KINASE 2, CYCLIN A, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: complex (transferase-cyclin), cyclin, cdk, phosphorylation, complex (transferase-cyclin) complex, complex (transferase/cyclin)
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P20248
• Total number of polymer chains: 4
• Total formula weight: 128702.36

Authors

Jeffrey, P.D.,Russo, A.A.,Pavletich, N.P. (deposition date: 1996-07-14, release date: 1997-01-27, Last modification date: 2024-02-07)

Primary citation

Jeffrey, P.D.,Russo, A.A.,Polyak, K.,Gibbs, E.,Hurwitz, J.,Massague, J.,Pavletich, N.P.
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.
Nature, 376:313-320, 1995

PubMed Abstract: The crystal structure of the human cyclinA-cyclin-dependent kinase2 (CDK2)-ATP complex has been determined at 2.3 A resolution. CyclinA binds to one side of CDK2's catalytic cleft, inducing large conformational changes in its PSTAIRE helix and T-loop. These changes activate the kinase by realigning active site residues and relieving the steric blockade at the entrance of the catalytic cleft.

PubMed: 7630397
DOI: 10.1038/376313a0

Experimental method

X-RAY DIFFRACTION (2.3 Å)