1DI8

THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH 4-[3-HYDROXYANILINO]-6,7-DIMETHOXYQUINAZOLINE

Summary for 1DI8

Related1DI9
DescriptorCYCLIN-DEPENDENT KINASE 2, 4-[3-HYDROXYANILINO]-6,7-DIMETHOXYQUINAZOLINE (3 entities in total)
Functional Keywordsserine/threonine protein kinase, cell cycle, atp-binding, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight34273.8
Authors
Shewchuk, L.,Hassell, A.,Kuyper, L.F. (deposition date: 1999-11-29, release date: 2000-11-29, Last modification date: 2011-07-13)
Primary citation
Shewchuk, L.,Hassell, A.,Wisely, B.,Rocque, W.,Holmes, W.,Veal, J.,Kuyper, L.F.
Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase.
J.Med.Chem., 43:133-138, 2000
PubMed: 10633045 (PDB entries with the same primary citation)
DOI: 10.1021/jm990401t
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers100.4%1.6%10.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution