1DI9
THE STRUCTURE OF P38 MITOGEN-ACTIVATED PROTEIN KINASE IN COMPLEX WITH 4-[3-METHYLSULFANYLANILINO]-6,7-DIMETHOXYQUINAZOLINE
Summary for 1DI9
Entry DOI | 10.2210/pdb1di9/pdb |
Related | 1DI8 |
Descriptor | P38 KINASE, 4-[3-METHYLSULFANYLANILINO]-6,7-DIMETHOXYQUINAZOLINE (3 entities in total) |
Functional Keywords | serine/threonine protein kinase, map kinase, p38, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 41670.60 |
Authors | Shewchuk, L.,Hassell, A.,Kuyper, L.F. (deposition date: 1999-11-29, release date: 2000-11-29, Last modification date: 2024-02-07) |
Primary citation | Shewchuk, L.,Hassell, A.,Wisely, B.,Rocque, W.,Holmes, W.,Veal, J.,Kuyper, L.F. Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase. J.Med.Chem., 43:133-138, 2000 Cited by PubMed: 10633045DOI: 10.1021/jm990401t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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