1DI9

THE STRUCTURE OF P38 MITOGEN-ACTIVATED PROTEIN KINASE IN COMPLEX WITH 4-[3-METHYLSULFANYLANILINO]-6,7-DIMETHOXYQUINAZOLINE

Summary for 1DI9

Related1DI8
DescriptorP38 KINASE, 4-[3-METHYLSULFANYLANILINO]-6,7-DIMETHOXYQUINAZOLINE (3 entities in total)
Functional Keywordsserine/threonine protein kinase, map kinase, p38, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm (By similarity) Q16539
Total number of polymer chains1
Total molecular weight41670.6
Authors
Shewchuk, L.,Hassell, A.,Kuyper, L.F. (deposition date: 1999-11-29, release date: 2000-11-29, Last modification date: 2011-07-13)
Primary citation
Shewchuk, L.,Hassell, A.,Wisely, B.,Rocque, W.,Holmes, W.,Veal, J.,Kuyper, L.F.
Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase.
J.Med.Chem., 43:133-138, 2000
PubMed: 10633045 (PDB entries with the same primary citation)
DOI: 10.1021/jm990401t
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers90.6%0.7%2.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution