1E1X

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU6027

Summary for 1E1X

Related1HCK 1FIN 1HCL 1AQ1 1JST 1JSU 1BUH 1B38 1B39 1CKP 1E1V
DescriptorCYCLIN-DEPENDENT PROTEIN KINASE 2, 6-CYCLOHEXYLMETHYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINE (3 entities in total)
Functional Keywordsprotein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total molecular weight34253.81
Authors
Endicott, J.A.,Noble, M.E.M.,Johnson, L.N. (deposition date: 2000-05-11, release date: 2001-05-10, Last modification date: 2019-03-06)
Primary citation
Arris, C.E.,Boyle, F.T.,Calvert, A.H.,Curtin, N.J.,Endicott, J.A.,Garman, E.F.,Gibson, A.E.,Golding, B.T.,Grant, S.,Griffin, R.J.,Jewsbury, P.,Johnson, L.N.,Lawrie, A.M.,Newell, D.R.,Noble, M.E.M.,Sausville, E.A.,Schultz, R.,Yu, W.
Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles.
J.Med.Chem., 43:2797-, 2000
PubMed: 10956187 (PDB entries with the same primary citation)
DOI: 10.1021/JM990628O
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.85 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers150 6.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report