Crystal structure of human CDK2 (unphosphorylated) in complex with PKF049-365

Summary for 1JVP

DescriptorCell division protein kinase 2, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE (3 entities in total)
Functional Keywordsprotein kinase, cell division, cell cycle, enzyme inhibitors, drug design, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight34209.76
Rondeau, J.M. (deposition date: 2001-08-31, release date: 2001-12-21, Last modification date: 2011-07-13)
Primary citation
Furet, P.,Meyer, T.,Strauss, A.,Raccuglia, S.,Rondeau, J.M.
Structure-based design and protein X-ray analysis of a protein kinase inhibitor.
Bioorg.Med.Chem.Lett., 12:221-224, 2002
PubMed: 11755359 (PDB entries with the same primary citation)
DOI: 10.1016/S0960-894X(01)00715-6
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2571908.3%12.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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