Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271

Summary for 2G9X

DescriptorCell division protein kinase 2, Cyclin-A2, 3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL, ... (4 entities in total)
Functional Keywordstransferase, serine/threonine protein kinase, atp-binding, cell cycle, phosphorylation, transferase-cell cycle complex, transferase/cell cycle
Biological sourceHomo sapiens (human)
Cellular locationNucleus P30274
Total number of polymer chains4
Total molecular weight129269.56
Echalier, A.,Endicott, J.A.,Noble, M.E. (deposition date: 2006-03-07, release date: 2006-05-23, Last modification date: 2011-07-13)
Primary citation
Griffin, R.J.,Henderson, A.,Curtin, N.J.,Echalier, A.,Endicott, J.A.,Hardcastle, I.R.,Newell, D.R.,Noble, M.E.,Wang, L.Z.,Golding, B.T.
Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination.
J.Am.Chem.Soc., 128:6012-6013, 2006
PubMed: 16669651 (PDB entries with the same primary citation)
DOI: 10.1021/ja060595j
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26361.0%4.6%4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report