2G9X
Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Cell division protein kinase 2 | polymer | 299 | 34143.5 | 2 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (human) | p33 protein kinase |
| 2 | B, D (B, D) | Cyclin-A2 | polymer | 262 | 30002.6 | 2 | UniProt (P30274) Pfam (PF00134) Pfam (PF02984) | Bos taurus (cattle) | Cyclin-A |
| 3 | E, F (A, C) | 3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL | non-polymer | 488.6 | 2 | Chemie (NU5) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 161 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
B, D: 172 - 432 (UniProt: P30274)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | cloning artifact |
| Tpo 160 | Thr 160 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| Gly 171 | - | cloning artifact |
| Leu 432 | Val 406 | see remark 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 128292.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 977.2 | |
| All* | Total formula weight | 129269.6 |
