2G9X
Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Cell division protein kinase 2 | polymer | 299 | 34143.5 | 2 | UniProt (P24941) Pfam (PF00069) In PDB | Homo sapiens (human) | p33 protein kinase |
2 | B, D | Cyclin-A2 | polymer | 262 | 30002.6 | 2 | UniProt (P30274) Pfam (PF00134) Pfam (PF02984) In PDB | Bos taurus (cattle) | Cyclin-A |
3 | A, C | 3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL | non-polymer | 488.6 | 2 | Chemie (NU5) | |||
4 | water | water | 18.0 | 161 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
B, D: 172 - 432 (UniProt: P30274)
PDB | External Database | Details |
---|---|---|
Ser 0 | - | cloning artifact |
Tpo 160 | Thr 160 | modified residue |
PDB | External Database | Details |
---|---|---|
Gly 171 | - | cloning artifact |
Leu 432 | Val 406 | see remark 999 |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 128292.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 977.2 | |
All* | Total formula weight | 129269.6 |