2B52

Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562

Summary for 2B52

Entry DOI	10.2210/pdb2b52/pdb
Related	2B53 2B54 2B55
Descriptor	Cell division protein kinase 2, 1-(3-(2,4-DIMETHYLTHIAZOL-5-YL)-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)-3-(4-METHYLPIPERAZIN-1-YL)UREA (3 entities in total)
Functional Keywords	protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34414.01
Authors	Muckelbauer, J. (deposition date: 2005-09-27, release date: 2005-10-11, Last modification date: 2024-02-14)
Primary citation	Yue, E.W.,Dimeo, S.V.,Higley, C.A.,Markwalder, J.A.,Burton, C.R.,Benfield, P.A.,Grafstrom, R.H.,Cox, S.,Muckelbauer, J.K.,Smallwood, A.,Chen, H.,Chang, C.-H.,Trainor, G.L.,Seitz, S.P. Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. Part 4: Heterocycles at C3 Bioorg.Med.Chem.Lett., 14:343-346, 2004 Cited by PubMed Abstract: New indeno[1,2-c]pyrazol-4-one cyclin dependent kinase inhibitors have been disclosed. The most promising compounds are nanomolar enzyme inhibitors with excellent activity against tumor cells. The most advanced compound retains cell culture activity even in the presence of human serum proteins. The most advanced compound did not kill the normal fibroblast line AG1523. PubMed: 14698155 DOI: 10.1016/j.bmcl.2003.11.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.88 Å)

Structure validation