2B53

Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325

Summary for 2B53

Entry DOI	10.2210/pdb2b53/pdb
Related	2B52 2B54 2B55
Descriptor	Cell division protein kinase 2, 6-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE (3 entities in total)
Functional Keywords	protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34336.86
Authors	Muckelbauer, J. (deposition date: 2005-09-27, release date: 2005-10-11, Last modification date: 2024-02-14)
Primary citation	Sielecki, T.M.,Johnson, T.L.,Liu, J.,Muckelbauer, J.K.,Grafstrom, R.H.,Cox, S.,Boylan, J.,Burton, C.R.,Chen, H.,Smallwood, A.,Chang, C.-H.,Boisclair, M.,Benfield, P.A.,Trainor, G.L.,Seitz, S.P. Quinazolines as Cyclin Dependent Kinase Inhibitors Bioorg.Med.Chem.Lett., 11:1157-1160, 2001 Cited by PubMed Abstract: Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined. PubMed: 11354366 DOI: 10.1016/S0960-894X(01)00185-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation