Crystal Structure of Human Cyclin-Dependent Kinase 2 Complexed with a Nucleoside Inhibitor

Summary for 1PF8

DescriptorCell division protein kinase 2, (3Z)-3-(1H-IMIDAZOL-5-YLMETHYLENE)-5-METHOXY-1H-INDOL-2(3H)-ONE (2 entities in total)
Functional Keywordstransferase, serine/threonine protein kinase, atp-binding, cell cycle, cell division, mitosis, phosphorylation, su9516, inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome P24941
Total number of polymer chains1
Total molecular weight34217.73
Moshinsky, D.J.,Bellamacina, R.C.,Boisvert, D.C.,Huang, P.,Hui, T.,Jancarik, J.,Kim, S.H.,Rice, A.G. (deposition date: 2003-05-24, release date: 2003-12-23, Last modification date: 2014-04-16)
Primary citation
Moshinsky, D.J.,Bellamacina, C.R.,Boisvert, D.C.,Huang, P.,Hui, T.,Jancarik, J.,Kim, S.H.,Rice, A.G.
SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2.
Biochem.Biophys.Res.Commun., 310:1026-1031, 2003
PubMed: 14550307 (PDB entries with the same primary citation)
DOI: 10.1016/j.bbrc.2003.09.114
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.311100.7%6.5%12.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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