1OIY

Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor

Summary for 1OIY

Related1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1G5S 1GIH 1GII 1GIJ 1GY3 1GZ8 1H00 1H01 1H06 1H07 1H08 1H0U 1H0V 1H0W 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1HCK 1HCL 1JSV 1JVP 1KE5 1KE6 1KE7 1KE8 1KE9 1QMZ 1FVV 1JST 1JSU 1OI9 1OGU 1OIU 1PKD
DescriptorCELL DIVISION PROTEIN KINASE 2, CYCLIN A2, 4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE, ... (6 entities in total)
Functional Keywordskinase, transferase, serine/threonine-protein kinase, atp-binding, cell cycle, cell division, mitosis, phosphorylation
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus 1OIY
Total number of polymer chains4
Total molecular weight129452.21
Authors
Pratt, D.J.,Endicott, J.A.,Noble, M.E.M. (deposition date: 2003-06-26, release date: 2004-07-13, Last modification date: 2011-07-13)
Primary citation
Hardcastle, I.R.,Arris, C.E.,Bentley, J.,Boyle, F.T.,Chen, Y.,Curtin, N.J.,Endicott, J.A.,Gibson, A.E.,Golding, B.T.,Griffin, R.J.,Jewsbury, P.,Menyerol, J.,Mesguiche, V.,Newell, D.R.,Noble, M.E.M.,Pratt, D.J.,Wang, L.-Z.,Whitfield, H.J.
N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2
J.Med.Chem., 47:3710-, 2004
PubMed: 15239650 (PDB entries with the same primary citation)
DOI: 10.1021/JM0311442
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.292192.1%12.0%8.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution