1KE8

CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE

Summary for 1KE8

Entry DOI	10.2210/pdb1ke8/pdb
Related	1KE5 1KE6 1KE7 1KE9
Descriptor	CELL DIVISION PROTEIN KINASE 2, 4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE (3 entities in total)
Functional Keywords	cyclin kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Total number of polymer chains	1
Total formula weight	34374.95
Authors	Bramson, H.N.,Corona, J.,Davis, S.T.,Dickerson, S.H.,Edelstein, M.,Frye, S.V.,Gampe, R.T.,Hassell, A.M.,Shewchuk, L.M.,Kuyper, L.F. (deposition date: 2001-11-14, release date: 2002-05-14, Last modification date: 2023-08-16)
Primary citation	Bramson, H.N.,Corona, J.,Davis, S.T.,Dickerson, S.H.,Edelstein, M.,Frye, S.V.,Gampe Jr., R.T.,Harris, P.A.,Hassell, A.,Holmes, W.D.,Hunter, R.N.,Lackey, K.E.,Lovejoy, B.,Luzzio, M.J.,Montana, V.,Rocque, W.J.,Rusnak, D.,Shewchuk, L.,Veal, J.M.,Walker, D.H.,Kuyper, L.F. Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis. J.Med.Chem., 44:4339-4358, 2001 Cited by PubMed: 11728181 DOI: 10.1021/jm010117d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation