Crystal structure of cdk2 with an aminoimidazo pyridine inhibitor

Summary for 1YKR

DescriptorCell division protein kinase 2, 4-{[6-(2,6-DICHLOROBENZOYL)IMIDAZO[1,2-A]PYRIDIN-2-YL]AMINO}BENZENESULFONAMIDE (3 entities in total)
Functional Keywordscell cycle division protein kinase 2, cdk2, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight34437.81
Hamdouchi, C.,Zhong, B.,Mendoza, J.,Jaramillo, C.,Zhang, F.,Brooks, H.B. (deposition date: 2005-01-18, release date: 2006-01-24, Last modification date: 2011-07-13)
Primary citation
Hamdouchi, C.,Zhong, B.,Mendoza, J.,Collins, E.,Jaramillo, C.,De Diego, J.E.,Robertson, D.,Spencer, C.D.,Anderson, B.D.,Watkins, S.A.,Zhang, F.,Brooks, H.B.
Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases
Bioorg.Med.Chem.Lett., 15:1943-1947, 2005
PubMed: 15780638 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2005.01.052
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers181.7%6.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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