1OIT

Imidazopyridines: a potent and selective class of Cyclin-dependent Kinase inhibitors identified through Structure-based hybridisation

Summary for 1OIT

Related1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1GZ8 1H00 1H01 1H06 1H07 1H08 1H0U 1H0V 1H0W 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1HCK 1HCL 1JST 1JSU 1JSV 1JVP 1KE5 1KE6 1KE7 1KE8 1KE9 1OGU 1OI9 1OIQ 1OIR 1OIU 1OIY 1OKU 1OKV 1OKW 1OL1 1OL2 1P2A 1P5E 1PKD 1QMZ
DescriptorCELL DIVISION PROTEIN KINASE 2, 4-[(4-IMIDAZO[1,2-A]PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO]BENZENESULFONAMIDE (3 entities in total)
Functional Keywordskinase, protein kinase
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total molecular weight34384.92
Authors
Beattie, J.F.,Breault, G.A.,Byth, K.F.,Culshaw, J.D.,Ellston, R.P.A.,Green, S.,Minshull, C.A.,Norman, R.A.,Pauptit, R.A.,Thomas, A.P.,Jewsbury, P.J. (deposition date: 2003-06-24, release date: 2003-09-04, Last modification date: 2011-07-13)
Primary citation
Anderson, M.,Beattie, J.F.,Breault, G.A.,Breed, J.,Byth, K.F.,Culshaw, J.D.,Ellston, R.P.A.,Green, S.,Minshull, C.A.,Norman, R.A.,Pauptit, R.A.,Stanway, J.,Thomas, A.P.,Jewsbury, P.J.
Imidazo[1,2-A]Pyridines: A Potent and Selective Class of Cyclin-Dependent Kinase Inhibitors Identified Through Structure-Based Hybridisation
Bioorg.Med.Chem.Lett., 13:3021-, 2003
PubMed: 12941325 (PDB entries with the same primary citation)
DOI: 10.1016/S0960-894X(03)00638-3
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.252606.7%13.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution