2A4L

Human cyclin-dependent kinase 2 in complex with roscovitine

Summary for 2A4L

Related1HCK
DescriptorHomo sapiens cyclin-dependent kinase 2, R-ROSCOVITINE (3 entities in total)
Functional Keywordstransferase, serine/threonine protein kinase, atp-binding, cell cycle, cell division, roscovitine, phosphorylation
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight34330.94
Authors
De Azevedo Jr., W.F.,Kim, S.H. (deposition date: 2005-06-29, release date: 2006-10-03, Last modification date: 2017-10-11)
Primary citation
De Azevedo, W.F.,Leclerc, S.,Meijer, L.,Havlicek, L.,Strnad, M.,Kim, S.H.
Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine.
Eur.J.Biochem., 243:518-526, 1997
PubMed: 9030780 (PDB entries with the same primary citation)
DOI: 10.1111/j.1432-1033.1997.0518a.x
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.252150.4%16.3%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report