2A0C

Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor

Summary for 2A0C

DescriptorCell division protein kinase 2, 2-{[(2-{[(1R)-1-(HYDROXYMETHYL)PROPYL]AMINO}-9-ISOPROPYL-9H-PURIN-6-YL)AMINO]METHYL}PHENOL (3 entities in total)
Functional Keywordsprotein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase, serine/threonine-protein kinase, atp-binding
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight34346.94
Authors
Krystof, V.,McNae, I.W.,Walkinshaw, M.D.,Fischer, P.M.,Muller, P.,Vojtesek, B.,Orsag, M.,Havlicek, L.,Strnad, M. (deposition date: 2005-06-16, release date: 2006-01-24, Last modification date: 2011-07-13)
Primary citation
Krystof, V.,McNae, I.W.,Walkinshaw, M.D.,Fischer, P.M.,Muller, P.,Vojtesek, B.,Orsag, M.,Havlicek, L.,Strnad, M.
Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor
Cell.Mol.Life Sci., 62:1763-1771, 2005
PubMed: 16003486 (PDB entries with the same primary citation)
DOI: 10.1007/s00018-005-5185-1
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.95 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.208110.7%12.4%13.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report