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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

2A0C

Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
X0000082biological_processG1/S transition of mitotic cell cycle
X0000086biological_processG2/M transition of mitotic cell cycle
X0000122biological_processnegative regulation of transcription by RNA polymerase II
X0000166molecular_functionnucleotide binding
X0000287molecular_functionmagnesium ion binding
X0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
X0000723biological_processtelomere maintenance
X0000781cellular_componentchromosome, telomeric region
X0000793cellular_componentcondensed chromosome
X0000805cellular_componentX chromosome
X0000806cellular_componentY chromosome
X0001673cellular_componentmale germ cell nucleus
X0004672molecular_functionprotein kinase activity
X0004674molecular_functionprotein serine/threonine kinase activity
X0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
X0005515molecular_functionprotein binding
X0005524molecular_functionATP binding
X0005634cellular_componentnucleus
X0005635cellular_componentnuclear envelope
X0005654cellular_componentnucleoplasm
X0005667cellular_componenttranscription regulator complex
X0005737cellular_componentcytoplasm
X0005768cellular_componentendosome
X0005813cellular_componentcentrosome
X0005829cellular_componentcytosol
X0005856cellular_componentcytoskeleton
X0006260biological_processDNA replication
X0006281biological_processDNA repair
X0006338biological_processchromatin remodeling
X0006351biological_processDNA-templated transcription
X0006468biological_processprotein phosphorylation
X0006813biological_processpotassium ion transport
X0006974biological_processDNA damage response
X0007099biological_processcentriole replication
X0007165biological_processsignal transduction
X0007265biological_processRas protein signal transduction
X0007346biological_processregulation of mitotic cell cycle
X0008284biological_processpositive regulation of cell population proliferation
X0010389biological_processregulation of G2/M transition of mitotic cell cycle
X0010468biological_processregulation of gene expression
X0015030cellular_componentCajal body
X0016301molecular_functionkinase activity
X0016740molecular_functiontransferase activity
X0018105biological_processpeptidyl-serine phosphorylation
X0019904molecular_functionprotein domain specific binding
X0030332molecular_functioncyclin binding
X0031453biological_processpositive regulation of heterochromatin formation
X0031571biological_processmitotic G1 DNA damage checkpoint signaling
X0031848biological_processprotection from non-homologous end joining at telomere
X0032298biological_processpositive regulation of DNA-templated DNA replication initiation
X0035173molecular_functionhistone kinase activity
X0043247biological_processtelomere maintenance in response to DNA damage
X0043687biological_processpost-translational protein modification
X0045740biological_processpositive regulation of DNA replication
X0045893biological_processpositive regulation of DNA-templated transcription
X0046872molecular_functionmetal ion binding
X0051298biological_processcentrosome duplication
X0051301biological_processcell division
X0051321biological_processmeiotic cell cycle
X0071732biological_processcellular response to nitric oxide
X0090398biological_processcellular senescence
X0097123cellular_componentcyclin A1-CDK2 complex
X0097124cellular_componentcyclin A2-CDK2 complex
X0097134cellular_componentcyclin E1-CDK2 complex
X0097135cellular_componentcyclin E2-CDK2 complex
X0097472molecular_functioncyclin-dependent protein kinase activity
X0106310molecular_functionprotein serine kinase activity
X1905784biological_processregulation of anaphase-promoting complex-dependent catabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE CK9 X 500
ChainResidue
XILE10
XLYS89
XGLN131
XASN132
XLEU134
XALA144
XHOH517
XGLY11
XGLU12
XVAL18
XALA31
XPHE80
XGLU81
XLEU83
XHIS84
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGVVYkArnkltgev..........VALK
ChainResidueDetails
XILE10-LYS33
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI
ChainResidueDetails
XVAL123-ILE135
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsActive site: {"description":"Proton acceptor"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues15
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17095507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21565702","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21565702","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues3
DetailsSite: {"description":"CDK7 binding","evidences":[{"source":"PubMed","id":"17373709","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"1396589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17095507","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by WEE1","evidences":[{"source":"PubMed","id":"1396589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17095507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by CAK and CCRK","evidences":[{"source":"PubMed","id":"1396589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14597612","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16325401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17095507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17570665","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20147522","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360007","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21565702","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28666995","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
XGLN131
XASP127
site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
XASP127
XLYS129
site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
XASP127
XLYS129
XTHR165
site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
XASP127
XLYS129
XASN132

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PDB entries from 2025-07-30

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