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2A0C

Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
X0000082biological_processG1/S transition of mitotic cell cycle
X0000086biological_processG2/M transition of mitotic cell cycle
X0000122biological_processnegative regulation of transcription by RNA polymerase II
X0000166molecular_functionnucleotide binding
X0000287molecular_functionmagnesium ion binding
X0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
X0000781cellular_componentchromosome, telomeric region
X0000793cellular_componentcondensed chromosome
X0000805cellular_componentX chromosome
X0000806cellular_componentY chromosome
X0001673cellular_componentmale germ cell nucleus
X0004672molecular_functionprotein kinase activity
X0004674molecular_functionprotein serine/threonine kinase activity
X0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
X0005515molecular_functionprotein binding
X0005524molecular_functionATP binding
X0005634cellular_componentnucleus
X0005635cellular_componentnuclear envelope
X0005654cellular_componentnucleoplasm
X0005667cellular_componenttranscription regulator complex
X0005737cellular_componentcytoplasm
X0005768cellular_componentendosome
X0005813cellular_componentcentrosome
X0005829cellular_componentcytosol
X0005856cellular_componentcytoskeleton
X0006260biological_processDNA replication
X0006281biological_processDNA repair
X0006338biological_processchromatin remodeling
X0006351biological_processDNA-templated transcription
X0006468biological_processprotein phosphorylation
X0006813biological_processpotassium ion transport
X0006974biological_processDNA damage response
X0007049biological_processcell cycle
X0007099biological_processcentriole replication
X0007165biological_processsignal transduction
X0007265biological_processRas protein signal transduction
X0007346biological_processregulation of mitotic cell cycle
X0008284biological_processpositive regulation of cell population proliferation
X0010033biological_processresponse to organic substance
X0010389biological_processregulation of G2/M transition of mitotic cell cycle
X0010468biological_processregulation of gene expression
X0015030cellular_componentCajal body
X0016301molecular_functionkinase activity
X0016310biological_processphosphorylation
X0016740molecular_functiontransferase activity
X0018105biological_processpeptidyl-serine phosphorylation
X0019904molecular_functionprotein domain specific binding
X0030332molecular_functioncyclin binding
X0031453biological_processpositive regulation of heterochromatin formation
X0031571biological_processmitotic G1 DNA damage checkpoint signaling
X0032298biological_processpositive regulation of DNA-templated DNA replication initiation
X0035173molecular_functionhistone kinase activity
X0043687biological_processpost-translational protein modification
X0045740biological_processpositive regulation of DNA replication
X0045893biological_processpositive regulation of DNA-templated transcription
X0046872molecular_functionmetal ion binding
X0051298biological_processcentrosome duplication
X0051301biological_processcell division
X0051321biological_processmeiotic cell cycle
X0071732biological_processcellular response to nitric oxide
X0090398biological_processcellular senescence
X0097123cellular_componentcyclin A1-CDK2 complex
X0097124cellular_componentcyclin A2-CDK2 complex
X0097134cellular_componentcyclin E1-CDK2 complex
X0097135cellular_componentcyclin E2-CDK2 complex
X0097472molecular_functioncyclin-dependent protein kinase activity
X0106310molecular_functionprotein serine kinase activity
X1905784biological_processregulation of anaphase-promoting complex-dependent catabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE CK9 X 500
ChainResidue
XILE10
XLYS89
XGLN131
XASN132
XLEU134
XALA144
XHOH517
XGLY11
XGLU12
XVAL18
XALA31
XPHE80
XGLU81
XLEU83
XHIS84

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGVVYkArnkltgev..........VALK
ChainResidueDetails
XILE10-LYS33

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI
ChainResidueDetails
XVAL123-ILE135

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
XASP127

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
ChainResidueDetails
XILE10
XLYS33
XGLU81
XASP86
XLYS129

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:21565702
ChainResidueDetails
XASN132
XASP145

site_idSWS_FT_FI4
Number of Residues3
DetailsSITE: CDK7 binding
ChainResidueDetails
XLYS9
XLYS88
XLEU166

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378
ChainResidueDetails
XMET1

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
XLYS6

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507
ChainResidueDetails
XTHR14

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by WEE1 => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507, ECO:0007744|PubMed:19690332
ChainResidueDetails
XTYR15

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19369195
ChainResidueDetails
XTYR19

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CAK and CCRK => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:14597612, ECO:0000269|PubMed:16325401, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:17570665, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:21565702, ECO:0000305|PubMed:28666995
ChainResidueDetails
XTHR160

218853

PDB entries from 2024-04-24

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