Author results

3V19
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
Descriptor:Insulin, ZINC ION, CHLORIDE ION, ...
Authors:Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
3V1G
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
Descriptor:Insulin, ZINC ION, PHENOL, ...
Authors:Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
1Q4V
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CRYSTAL STRUCTURE OF ALLO-ILEA2-INSULIN, AN INACTIVE CHIRAL ANALOGUE: IMPLICATIONS FOR THE MECHANISM OF RECEPTOR
Descriptor:Insulin, ZINC ION, PHENOL
Authors:Wan, Z.L., Xu, B., Chu, Y.C., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2003-08-04
Release date:2003-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of allo-Ile(A2)-insulin, an inactive chiral analogue: implications for the mechanism of receptor binding.
Biochemistry, 42, 2003
1XW7
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DIABETES-ASSOCIATED MUTATIONS IN HUMAN INSULIN: CRYSTAL STRUCTURE AND PHOTO-CROSS-LINKING STUDIES OF A-CHAIN VARIANT INSULIN WAKAYAMA
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Wan, Z.L., Huang, K., Xu, B., Chu, Y.C., Hu, S.Q., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2004-10-29
Release date:2005-04-12
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin wakayama
Biochemistry, 44, 2005
2L1Y
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NMR STRUCTURE OF HUMAN INSULIN MUTANT GLY-B20-D-ALA, GLY-B23-D-ALA PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:Insulin A chain, Insulin B chain
Authors:Wan, Z.L., Hua, Q.X., Huang, K., Hu, S.Q., Philips, N.B., Katsoyannis, J.W., Weiss, M.A.
Deposit date:2010-08-09
Release date:2011-08-31
Method:SOLUTION NMR
Cite:Chiral Protein Engineering and its Application in G Health
To be Published
2L1Z
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NMR STRUCTURE OF HUMAN INSULIN MUTANT GLY-B20-D-ALA, GLY-B23-D-ALA PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:Insulin A chain, Insulin B chain
Authors:Wan, Z.L., Hua, Q.X., Huang, K., Hu, S.Q., Philips, N.B., Katsoyannis, J.W., Weiss, M.A.
Deposit date:2010-08-09
Release date:2011-08-31
Method:SOLUTION NMR
Cite:Chiral Protein Engineering and its Application in G Health
To be Published
3KQ6
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ENHANCING THE THERAPEUTIC PROPERTIES OF A PROTEIN BY A DESIGNED ZINC-BINDING SITE, STRUCTURAL PRINCIPLES OF A NOVEL LONG-ACTING INSULIN ANALOG
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Wan, Z.L., Hu, S.Q., Whittaker, L., Phillips, N.B., Whittake, J., Ismail-Beigi, F., Weiss, M.A.
Deposit date:2009-11-17
Release date:2010-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285, 2010
3P2X
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIARAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
Descriptor:Insulin, ZINC ION, CHLORIDE ION, ...
Authors:Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3P33
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIRAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3ROV
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2011-04-26
Release date:2012-05-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
2KQQ
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NMR STRUCTURE OF HUMAN INSULIN MUTANT GLY-B8-D-ALA, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:Insulin B chain, Insulin A chain
Authors:Hua, Q.X., Wan, Z.L., Zhao, M., Jia, W., Huang, K., Weiss, M.A.
Deposit date:2009-11-13
Release date:2010-11-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and Dynamics of an Turn-Stabilize But Ina Insulin Analog.
To be Published
3FQ9
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DESIGN OF AN INSULIN ANALOG WITH ENHANCED RECEPTOR-BINDING SELECTIVITY. RATIONALE, STRUCTURE, AND THERAPEUTIC IMPLICATIONS
Descriptor:Insulin, ZINC ION
Authors:Zhao, M., Wan, Z.L., Whittaker, L., Xu, B., Phillips, N., Katsoyannis, P., Whittaker, J., Weiss, M.A.
Deposit date:2009-01-07
Release date:2009-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.
J.Biol.Chem., 284, 2009
3GKY
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THE STRUCTURAL BASIS OF AN ER STRESS-ASSOCIATED BOTTLENECK IN A PROTEIN FOLDING LANDSCAPE
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Liu, M., Wan, Z.L., Chu, Y.C., Alddin, H., Klaproth, B., Weiss, M.A.
Deposit date:2009-03-11
Release date:2009-03-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY.
J.Biol.Chem., 284, 2009
3JSD
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2009-09-10
Release date:2010-09-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
3BXQ
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THE STRUCTURE OF A MUTANT INSULIN UNCOUPLES RECEPTOR BINDING FROM PROTEIN ALLOSTERY. AN ELECTROSTATIC BLOCK TO THE TR TRANSITION
Descriptor:insulin A chain, insulin B chain, ZINC ION
Authors:Wan, Z.L., Huang, K., Hu, S.Q., Whittaker, J., Weiss, M.A.
Deposit date:2008-01-14
Release date:2008-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
J.Biol.Chem., 283, 2008
1RWE
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ENHANCING THE ACTIVITY OF INSULIN AT RECEPTOR EDGE: CRYSTAL STRUCTURE AND PHOTO-CROSS-LINKING OF A8 ANALOGUES
Descriptor:insulin, Insulin, ZINC ION, ...
Authors:Wan, Z., Xu, B., Chu, Y.C., Li, B., Nakagawa, S.H., Qu, Y., Hu, S.Q., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2003-12-16
Release date:2005-02-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.
Biochemistry, 43, 2004
1LIA
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CRYSTAL STRUCTURE OF R-PHYCOERYTHRIN FROM POLYSIPHONIA AT 2.8 A RESOLUTION
Descriptor:R-PHYCOERYTHRIN, PHYCOCYANOBILIN, PHYCOUROBILIN
Authors:Liang, D.C., Jiang, T., Chang, W.R.
Deposit date:1996-01-29
Release date:1997-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of R-phycoerythrin from Polysiphonia urceolata at 2.8 A resolution.
J.Mol.Biol., 262, 1996
4P65
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CRYSTAL STRUCTURE OF AN CYCLOHEXYLALANINE SUBSTITUTED INSULIN ANALOG.
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Pandyarajan, V., Wan, Z., Weiss, M.A.
Deposit date:2014-03-21
Release date:2014-10-22
Last modified:2014-12-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Aromatic Anchor at an Invariant Hormone-Receptor Interface: FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN.
J.Biol.Chem., 289, 2014
1SDB
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PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN
Descriptor:DESB1-2 DESPENTAPEPTIDE (B26-B30) INSULIN
Authors:Liang, D.-C., Diao, J.-S.
Deposit date:1996-01-29
Release date:1997-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of monomeric porcine DesB1-B2 despentapeptide (B26-B30) insulin at 1.65 A resolution.
Acta Crystallogr.,Sect.D, 53, 1997
2MLI
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NMR STRUCTURE OF B25-(ALPHA, BETA)-DEHYDRO-PHENYLALANINE INSULIN
Descriptor:Insulin
Authors:Yang, Y., Weiss, M.
Deposit date:2014-02-27
Release date:2014-08-20
Last modified:2014-09-03
Method:SOLUTION NMR
Cite:Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
2MPI
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SOLUTION STRUCTURE OF B24G INSULIN
Descriptor:insulin chain A, insulin chain B
Authors:Yang, Y., Wickramasinghe, N.P., Hua, Q., Weiss, M.A.
Deposit date:2014-05-19
Release date:2014-12-24
Method:SOLUTION NMR
Cite:Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NIB
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CRYSTAL STRUCTURE OF HUMAN INSULIN MUTANT B20 D-ALA, B23 D-ALA
Descriptor:Insulin A chain, Insulin B chain
Authors:Menting, J.G., Lawrence, M.C.
Deposit date:2013-11-05
Release date:2014-08-27
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
4OGA
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INSULIN IN COMPLEX WITH SITE 1 OF THE HUMAN INSULIN RECEPTOR
Descriptor:Insulin A chain, Insulin B chain, monoclonal antibody fab 83-7 fragment - heavy chain, ...
Authors:Lawrence, M.C., Menting, J.G.
Deposit date:2014-01-15
Release date:2014-08-27
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
1J73
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CRYSTAL STRUCTURE OF AN UNSTABLE INSULIN ANALOG WITH NATIVE ACTIVITY.
Descriptor:insulin a, insulin b, ZINC ION
Authors:Wan, Z., Zhao, M., Nakagawa, S., Jia, W., Weiss, M.A.
Deposit date:2001-05-15
Release date:2001-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
1JCA
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NON-STANDARD DESIGN OF UNSTABLE INSULIN ANALOGUES WITH ENHANCED ACTIVITY
Descriptor:insulin a, insulin b, ZINC ION
Authors:Weiss, M.A., Wan, Z., Zhao, M., Chu, Y.-C., Nakagawa, S.H., Burke, G.T., Jia, W., Hellmich, R., Katsoyannis, P.G.
Deposit date:2001-06-08
Release date:2001-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002