2MPI
Solution structure of B24G insulin
Summary for 2MPI
Entry DOI | 10.2210/pdb2mpi/pdb |
NMR Information | BMRB: 19979 |
Descriptor | insulin chain A, insulin chain B (2 entities in total) |
Functional Keywords | insulin structure, insulin mutant, protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P01308 P01308 |
Total number of polymer chains | 2 |
Total formula weight | 5704.47 |
Authors | Yang, Y.,Wickramasinghe, N.P.,Hua, Q.,Weiss, M.A. (deposition date: 2014-05-19, release date: 2014-12-24, Last modification date: 2023-06-14) |
Primary citation | Menting, J.G.,Yang, Y.,Chan, S.J.,Phillips, N.B.,Smith, B.J.,Whittaker, J.,Wickramasinghe, N.P.,Whittaker, L.J.,Pandyarajan, V.,Wan, Z.L.,Yadav, S.P.,Carroll, J.M.,Strokes, N.,Roberts, C.T.,Ismail-Beigi, F.,Milewski, W.,Steiner, D.F.,Chauhan, V.S.,Ward, C.W.,Weiss, M.A.,Lawrence, M.C. Protective hinge in insulin opens to enable its receptor engagement. Proc.Natl.Acad.Sci.USA, 111:E3395-E3404, 2014 Cited by PubMed: 25092300DOI: 10.1073/pnas.1412897111 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report