2MPI

Solution structure of B24G insulin

Summary for 2MPI

• Entry DOI: 10.2210/pdb2mpi/pdb
• NMR Information: BMRB: 19979
• Descriptor: insulin chain A, insulin chain B (2 entities in total)
• Functional Keywords: insulin structure, insulin mutant, protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 2
• Total formula weight: 5704.47

Authors

Yang, Y.,Wickramasinghe, N.P.,Hua, Q.,Weiss, M.A. (deposition date: 2014-05-19, release date: 2014-12-24, Last modification date: 2023-06-14)

• Primary citation: Menting, J.G.,Yang, Y.,Chan, S.J.,Phillips, N.B.,Smith, B.J.,Whittaker, J.,Wickramasinghe, N.P.,Whittaker, L.J.,Pandyarajan, V.,Wan, Z.L.,Yadav, S.P.,Carroll, J.M.,Strokes, N.,Roberts, C.T.,Ismail-Beigi, F.,Milewski, W.,Steiner, D.F.,Chauhan, V.S.,Ward, C.W.,Weiss, M.A.,Lawrence, M.C.; Protective hinge in insulin opens to enable its receptor engagement.; Proc.Natl.Acad.Sci.USA, 111:E3395-E3404, 2014; PubMed: 25092300; DOI: 10.1073/pnas.1412897111

Experimental method

SOLUTION NMR