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3ROV
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BU of 3rov by Molmil
Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G.
Deposit date:2011-04-26
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
3JSD
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BU of 3jsd by Molmil
Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G.
Deposit date:2009-09-10
Release date:2010-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
1JCA
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BU of 1jca by Molmil
Non-standard Design of Unstable Insulin Analogues with Enhanced Activity
Descriptor: ZINC ION, insulin a, insulin b
Authors:Weiss, M.A, Wan, Z, Zhao, M, Chu, Y.-C, Nakagawa, S.H, Burke, G.T, Jia, W, Hellmich, R, Katsoyannis, P.G.
Deposit date:2001-06-08
Release date:2001-06-20
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
1J73
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BU of 1j73 by Molmil
Crystal structure of an unstable insulin analog with native activity.
Descriptor: ZINC ION, insulin a, insulin b
Authors:Wan, Z, Zhao, M, Nakagawa, S, Jia, W, Weiss, M.A.
Deposit date:2001-05-15
Release date:2001-05-30
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
6X4X
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BU of 6x4x by Molmil
B24Y DKP insulin
Descriptor: Insulin, Insulin chain A
Authors:Weiss, M.A, Yang, Y.
Deposit date:2020-05-24
Release date:2020-08-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Evolution of insulin at the edge of foldability and its medical implications.
Proc.Natl.Acad.Sci.USA, 117, 2020
1ZV1
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BU of 1zv1 by Molmil
Crystal structure of the dimerization domain of doublesex protein from D. melanogaster
Descriptor: Doublesex protein
Authors:Weiss, M.A, Bayrer, J.R, Wan, Z, Li, B, Phillips, N.B.
Deposit date:2005-06-01
Release date:2005-08-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Dimerization of doublesex is mediated by a cryptic ubiquitin-associated domain fold: implications for sex-specific gene regulation
J.Biol.Chem., 280, 2005
6U46
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BU of 6u46 by Molmil
Solution Structure of a Heat-Resistant Long-Acting Insulin Analog
Descriptor: Insulin
Authors:Yang, Y, Weiss, M.A.
Deposit date:2019-08-23
Release date:2020-08-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution Structure of a Heat-Resistant Long-Acting Insulin Analog
To Be Published
1SF1
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BU of 1sf1 by Molmil
NMR STRUCTURE OF HUMAN INSULIN under Amyloidogenic Condition, 15 STRUCTURES
Descriptor: INSULIN A CHAIN, Insulin
Authors:Weiss, M.A, Hua, Q.X.
Deposit date:2004-02-19
Release date:2004-03-30
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Mechanism of insulin fibrillation: the structure of insulin under amyloidogenic conditions resembles a protein-folding intermediate
J.Biol.Chem., 279, 2004
2LWZ
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BU of 2lwz by Molmil
NMR Structures of Single-chain Insulin
Descriptor: SINGLE-CHAIN INSULIN
Authors:Weiss, M.A, Yang, Y.
Deposit date:2012-08-09
Release date:2013-08-28
Method:SOLUTION NMR
Cite:Dynamic repair of an amyloidogenic protein: Insulin fibrillation is blocked by tethering a nascent alpha-helix
To be Published
1LKQ
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BU of 1lkq by Molmil
NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-GLY, VAL-A3-GLY, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor: INSULIN
Authors:Weiss, M.A, Hua, Q.X, Chu, Y.C, Jia, W, Philips, N.F, Wang, R.Y, Katsoyannis, P.G.
Deposit date:2002-04-25
Release date:2002-05-22
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing
J.Biol.Chem., 277, 2002
7ZNF
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BU of 7znf by Molmil
ALTERNATING ZINC FINGERS IN THE HUMAN MALE ASSOCIATED PROTEIN ZFY: 2D NMR STRUCTURE OF AN EVEN FINGER AND IMPLICATIONS FOR "JUMPING-LINKER" DNA RECOGNITION
Descriptor: ZINC FINGER, ZINC ION
Authors:Kochoyan, M, Keutmann, H.T, Weiss, M.A.
Deposit date:1991-08-22
Release date:1994-01-31
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition.
Biochemistry, 30, 1991
3P2X
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BU of 3p2x by Molmil
Insulin fibrillation is the Janus face of induced fit. A chiaral clamp stabilizes the native state at the expense of activity
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Hua, Q.X, Wan, Z.L, Huang, K, Hu, S.Q, Phillip, N.F, Jia, W.H, Whittingham, J, Dodson, G.G, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3P33
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BU of 3p33 by Molmil
Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Hua, Q.X, Wan, Z.L, Huang, K, Hu, S.Q, Phillip, N.F, Jia, W.H, Whittingham, J, Dodson, G.G, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3V19
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BU of 3v19 by Molmil
Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
3V1G
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BU of 3v1g by Molmil
Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
5ZNF
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BU of 5znf by Molmil
ALTERNATING ZINC FINGERS IN THE HUMAN MALE ASSOCIATED PROTEIN ZFY: 2D NMR STRUCTURE OF AN EVEN FINGER AND IMPLICATIONS FOR "JUMPING-LINKER" DNA RECOGNITION
Descriptor: ZINC FINGER, ZINC ION
Authors:Kochoyan, M, Keutmann, H.T, Weiss, M.A.
Deposit date:1991-08-22
Release date:1994-01-31
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition.
Biochemistry, 30, 1991
1Q4V
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BU of 1q4v by Molmil
CRYSTAL STRUCTURE OF ALLO-ILEA2-INSULIN, AN INACTIVE CHIRAL ANALOGUE: IMPLICATIONS FOR THE MECHANISM OF RECEPTOR
Descriptor: Insulin, PHENOL, ZINC ION
Authors:Wan, Z.L, Xu, B, Chu, Y.C, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2003-08-04
Release date:2003-08-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of allo-Ile(A2)-insulin, an inactive chiral analogue: implications for the mechanism of receptor binding.
Biochemistry, 42, 2003
3BXQ
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BU of 3bxq by Molmil
The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition
Descriptor: ZINC ION, insulin A chain, insulin B chain
Authors:Wan, Z.L, Huang, K, Hu, S.Q, Whittaker, J, Weiss, M.A.
Deposit date:2008-01-14
Release date:2008-05-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition.
J.Biol.Chem., 283, 2008
1QYP
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BU of 1qyp by Molmil
THERMOCOCCUS CELER RPB9, NMR, 25 STRUCTURES
Descriptor: RNA POLYMERASE II, ZINC ION
Authors:Wang, B, Jones, D.N.M, Kaine, B.P, Weiss, M.A.
Deposit date:1997-08-19
Release date:1997-12-24
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:High-resolution structure of an archaeal zinc ribbon defines a general architectural motif in eukaryotic RNA polymerases.
Structure, 6, 1998
1RWE
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BU of 1rwe by Molmil
Enhancing the activity of insulin at receptor edge: crystal structure and photo-cross-linking of A8 analogues
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Wan, Z, Xu, B, Chu, Y.C, Li, B, Nakagawa, S.H, Qu, Y, Hu, S.Q, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2003-12-16
Release date:2005-02-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.
Biochemistry, 43, 2004
3FQ9
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BU of 3fq9 by Molmil
Design of an insulin analog with enhanced receptor-binding selectivity. Rationale, structure, and therapeutic implications
Descriptor: Insulin, ZINC ION
Authors:Zhao, M, Wan, Z.L, Whittaker, L, Xu, B, Phillips, N, Katsoyannis, P, Whittaker, J, Weiss, M.A.
Deposit date:2009-01-07
Release date:2009-08-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.
J.Biol.Chem., 284, 2009
3GKY
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BU of 3gky by Molmil
The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:Liu, M, Wan, Z.L, Chu, Y.C, Alddin, H, Klaproth, B, Weiss, M.A.
Deposit date:2009-03-11
Release date:2009-03-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY.
J.Biol.Chem., 284, 2009
3KQ6
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BU of 3kq6 by Molmil
Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:Wan, Z.L, Hu, S.Q, Whittaker, L, Phillips, N.B, Whittake, J, Ismail-Beigi, F, Weiss, M.A.
Deposit date:2009-11-17
Release date:2010-02-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285, 2010
1HIQ
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BU of 1hiq by Molmil
PARADOXICAL STRUCTURE AND FUNCTION IN A MUTANT HUMAN INSULIN ASSOCIATED WITH DIABETES MELLITUS
Descriptor: INSULIN
Authors:Hua, Q.X, Shoelson, S.E, Inouye, K, Weiss, M.A.
Deposit date:1993-03-05
Release date:1994-01-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus.
Proc.Natl.Acad.Sci.USA, 90, 1993
1KMF
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BU of 1kmf by Molmil
NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-ALLO-ILE, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor: Insulin
Authors:Xu, B, Hua, Q.X, Nakagawa, S.H, Jia, W, Chu, Y.C, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2001-12-14
Release date:2002-01-09
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue.
J.Mol.Biol., 316, 2002

 

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