3KQ6

Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog

Summary for 3KQ6

Related1RWE
DescriptorInsulin A chain, Insulin B chain, ZINC ION, ... (6 entities in total)
Functional Keywordszinc-binding site, long-acting insulin analog, receptor binding, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, disulfide bond, glucose metabolism, hormone, pharmaceutical, secreted
Biological sourceHomo sapiens (Human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains4
Total molecular weight12088.7
Authors
Wan, Z.L.,Hu, S.Q.,Whittaker, L.,Phillips, N.B.,Whittake, J.,Ismail-Beigi, F.,Weiss, M.A. (deposition date: 2009-11-17, release date: 2010-02-23, Last modification date: 2011-07-13)
Primary citation
Phillips, N.B.,Wan, Z.L.,Whittaker, L.,Hu, S.Q.,Huang, K.,Hua, Q.X.,Whittaker, J.,Ismail-Beigi, F.,Weiss, M.A.
Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285:11755-11759, 2010
PubMed: 20181952 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.C110.105825
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers1401.1%6.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3kq6.pdb1.gz [57.29 KB])