3KQ6
Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Insulin A chain | polymer | 21 | 2429.8 | 2 | UniProt (P01308) | Homo sapiens | |
| 2 | B, D (B, D) | Insulin B chain | polymer | 30 | 3434.0 | 2 | UniProt (P01308) Pfam (PF00049) | Homo sapiens | |
| 3 | E, G, I (A, B, D) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | F, J (A, D) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | H (C) | PHENOL | non-polymer | 94.1 | 1 | Chemie (IPH) | |||
| 6 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 21 (UniProt: P01308)
| PDB | External Database | Details |
|---|---|---|
| His 4 | Glu 93 | engineered mutation |
| His 8 | Thr 97 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 11727.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 361.2 | |
| All* | Total formula weight | 12088.7 |
