Non-standard Design of Unstable Insulin Analogues with Enhanced Activity

Summary for 1JCA

Descriptorinsulin a, insulin b, ZINC ION, ... (4 entities in total)
Functional Keywordsa8-lysine human insulin, insulin receptor, hormone-growth factor complex, hormone/growth factor
Cellular locationSecreted P01308 P01308
Total number of polymer chains4
Total molecular weight11822.27
Weiss, M.A.,Wan, Z.,Zhao, M.,Chu, Y.-C.,Nakagawa, S.H.,Burke, G.T.,Jia, W.,Hellmich, R.,Katsoyannis, P.G. (deposition date: 2001-06-08, release date: 2001-06-20, Last modification date: 2011-07-13)
Primary citation
Weiss, M.A.,Wan, Z.,Zhao, M.,Chu, Y.C.,Nakagawa, S.H.,Burke, G.T.,Jia, W.,Hellmich, R.,Katsoyannis, P.G.
Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315:103-111, 2002
PubMed: 11779231 (PDB entries with the same primary citation)
DOI: 10.1006/jmbi.2001.5224
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers101.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution