1J73

Crystal structure of an unstable insulin analog with native activity.

Summary for 1J73

Related1TRZ
Descriptorinsulin a, insulin b, ZINC ION, ... (4 entities in total)
Functional Keywordsa8-diaminobutyric acid human insulin, hormone-receptor interface, hormone-growth factor complex, hormone/growth factor
Cellular locationSecreted P01308 P01308
Total number of polymer chains4
Total molecular weight11764.15
Authors
Wan, Z.,Zhao, M.,Nakagawa, S.,Jia, W.,Weiss, M.A. (deposition date: 2001-05-15, release date: 2001-05-30, Last modification date: 2011-07-13)
Primary citation
Weiss, M.A.,Wan, Z.,Zhao, M.,Chu, Y.C.,Nakagawa, S.H.,Burke, G.T.,Jia, W.,Hellmich, R.,Katsoyannis, P.G.
Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315:103-111, 2002
PubMed: 11779231 (PDB entries with the same primary citation)
DOI: 10.1006/jmbi.2001.5224
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
NMR Information
?

Structure validation

ClashscoreRamachandran outliersSidechain outliers61.1%8.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution