3FQ9

Design of an insulin analog with enhanced receptor-binding selectivity. Rationale, structure, and therapeutic implications

Summary for 3FQ9

• Entry DOI: 10.2210/pdb3fq9/pdb
• Related: 4INS
• Descriptor: Insulin, ZINC ION, ... (4 entities in total)
• Functional Keywords: receptor-binding, insulin design, rational, therapeutic implication, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, glucose metabolism, hormone, pharmaceutical, secreted
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 4
• Total formula weight: 11792.20

Authors

Zhao, M.,Wan, Z.L.,Whittaker, L.,Xu, B.,Phillips, N.,Katsoyannis, P.,Whittaker, J.,Weiss, M.A. (deposition date: 2009-01-07, release date: 2009-08-04, Last modification date: 2023-09-06)

• Primary citation: Zhao, M.,Wan, Z.L.,Whittaker, L.,Xu, B.,Phillips, N.B.,Katsoyannis, P.G.,Ismail-Beigi, F.,Whittaker, J.,Weiss, M.A.; Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.; J.Biol.Chem., 284:32178-32187, 2009; PubMed: 19773552; DOI: 10.1074/jbc.M109.028399

Experimental method

X-RAY DIFFRACTION (1.35 Å)