3FQ9
Design of an insulin analog with enhanced receptor-binding selectivity. Rationale, structure, and therapeutic implications
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Insulin | polymer | 21 | 2396.7 | 2 | UniProt (P01308) | Insulin A chain | |
| 2 | B, D (B, D) | Insulin | polymer | 30 | 3434.0 | 2 | UniProt (P01308) Pfam (PF00049) | Insulin B chain | |
| 3 | E, F (B, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 122 | Chemie (HOH) |
Sequence modifications
A, C: 2 - 21 (UniProt: P01308)
| PDB | External Database | Details |
|---|---|---|
| Dal 1 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 11661.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.8 | |
| All* | Total formula weight | 11792.2 |
