3JSD

Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus

Summary for 3JSD

Related1TRZ
DescriptorInsulin A chain, Insulin B chain, ZINC ION, ... (6 entities in total)
Functional Keywordsdiabetes mellitus, insulin's biosynthesis, proinsulin, insulin hexamer, carbohydrate metabolism, cleavage on pair of basic residues, disease mutation, disulfide bond, glucose metabolism, hormone, secreted
Cellular locationSecreted P01308 P01308
Total number of polymer chains4
Total molecular weight11959.19
Authors
Primary citation
Weiss, M.A.,Wan, Z.L.,Dodson, E.J.,Liu, M.,Xu, B.,Hua, Q.X.,Turkenburg, M.,Whittingham, J.,Nakagawa, S.H.,Huang, K.,Hu, S.Q.,Jia, W.H.,Wang, S.H.,Brange, J.,Whittaker, J.,Arvan, P.,Katsoyannis, P.G.,Dodson, G.G.
Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published,
Experimental method
X-RAY DIFFRACTION (2.5 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers1505.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 3jsd
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Molmil generated image of 3jsd
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Molmil generated image of 3jsd
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3jsd.pdb1.gz [52.59 KB])