4P65
Crystal structure of an cyclohexylalanine substituted insulin analog.
Summary for 4P65
Entry DOI | 10.2210/pdb4p65/pdb |
Descriptor | Insulin, PHENOL, ZINC ION, ... (6 entities in total) |
Functional Keywords | protein hormone, non-standard mutagenesis, hormone |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P01308 P01308 |
Total number of polymer chains | 12 |
Total formula weight | 35618.38 |
Authors | Pandyarajan, V.,Wan, Z.,Weiss, M.A. (deposition date: 2014-03-21, release date: 2014-10-22, Last modification date: 2023-09-27) |
Primary citation | Pandyarajan, V.,Smith, B.J.,Phillips, N.B.,Whittaker, L.,Cox, G.P.,Wickramasinghe, N.,Menting, J.G.,Wan, Z.L.,Whittaker, J.,Ismail-Beigi, F.,Lawrence, M.C.,Weiss, M.A. Aromatic Anchor at an Invariant Hormone-Receptor Interface: FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN. J.Biol.Chem., 289:34709-34727, 2014 Cited by PubMed: 25305014DOI: 10.1074/jbc.M114.608562 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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