4P65

Crystal structure of an cyclohexylalanine substituted insulin analog.

Summary for 4P65

DescriptorInsulin, PHENOL, ZINC ION, ... (6 entities in total)
Functional Keywordsprotein hormone, non-standard mutagenesis, hormone
Biological sourceHomo sapiens (Human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains12
Total molecular weight35618.38
Authors
Pandyarajan, V.,Wan, Z.,Weiss, M.A. (deposition date: 2014-03-21, release date: 2014-10-22, Last modification date: 2014-12-31)
Primary citation
Pandyarajan, V.,Smith, B.J.,Phillips, N.B.,Whittaker, L.,Cox, G.P.,Wickramasinghe, N.,Menting, J.G.,Wan, Z.L.,Whittaker, J.,Ismail-Beigi, F.,Lawrence, M.C.,Weiss, M.A.
Aromatic Anchor at an Invariant Hormone-Receptor Interface: FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN.
J.Biol.Chem., 289:34709-34727, 2014
PubMed: 25305014 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M114.608562
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.204801.2%8.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report