4P65

Crystal structure of an cyclohexylalanine substituted insulin analog.

Summary for 4P65

• Entry DOI: 10.2210/pdb4p65/pdb
• Descriptor: Insulin, PHENOL, ZINC ION, ... (6 entities in total)
• Functional Keywords: protein hormone, non-standard mutagenesis, hormone
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 12
• Total formula weight: 35618.38

Authors

Pandyarajan, V.,Wan, Z.,Weiss, M.A. (deposition date: 2014-03-21, release date: 2014-10-22, Last modification date: 2023-09-27)

• Primary citation: Pandyarajan, V.,Smith, B.J.,Phillips, N.B.,Whittaker, L.,Cox, G.P.,Wickramasinghe, N.,Menting, J.G.,Wan, Z.L.,Whittaker, J.,Ismail-Beigi, F.,Lawrence, M.C.,Weiss, M.A.; Aromatic Anchor at an Invariant Hormone-Receptor Interface: FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN.; J.Biol.Chem., 289:34709-34727, 2014; PubMed: 25305014; DOI: 10.1074/jbc.M114.608562

Experimental method

X-RAY DIFFRACTION (1.5 Å)