3ROV

Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus

Summary for 3ROV

Related1ZNJ
DescriptorInsulin, PHENOL, ZINC ION, ... (6 entities in total)
Functional Keywordszinc-binding site, long-acting insulin analog, receptor binding protein engineering, global health, insulin fibrillation, stabilizing, hormone
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains12
Total molecular weight35840.61
Authors
Primary citation
Weiss, M.A.,Wan, Z.L.,Dodson, E.J.,Liu, M.,Xu, B.,Hua, Q.X.,Turkenburg, M.,Whittingham, J.,Nakagawa, S.H.,Huang, K.,Hu, S.Q.,Jia, W.H.,Wang, S.H.,Brange, J.,Whittaker, J.,Arvan, P.,Katsoyannis, P.G.,Dodson, G.G.
Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published,
Experimental method
X-RAY DIFFRACTION (2.3 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.307431.9%7.6%8.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3rov
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Molmil generated image of 3rov
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Molmil generated image of 3rov
rotated about y axis by 90°