3ROV
Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
Summary for 3ROV
Entry DOI | 10.2210/pdb3rov/pdb |
Related | 1ZNJ |
Descriptor | Insulin, PHENOL, ZINC ION, ... (6 entities in total) |
Functional Keywords | zinc-binding site, long-acting insulin analog, receptor binding protein engineering, global health, insulin fibrillation, stabilizing, hormone |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P01308 P01308 |
Total number of polymer chains | 12 |
Total formula weight | 35840.61 |
Authors | Weiss, M.A.,Wan, Z.L.,Dodson, E.J.,Liu, M.,Xu, B.,Hua, Q.X.,Turkenburg, M.,Whittingham, J.,Nakagawa, S.H.,Huang, K.,Hu, S.Q.,Jia, W.H.,Wang, S.H.,Brange, J.,Whittaker, J.,Arvan, P.,Katsoyannis, P.G.,Dodson, G.G. (deposition date: 2011-04-26, release date: 2012-05-02, Last modification date: 2023-09-13) |
Primary citation | Weiss, M.A.,Wan, Z.L.,Dodson, E.J.,Liu, M.,Xu, B.,Hua, Q.X.,Turkenburg, M.,Whittingham, J.,Nakagawa, S.H.,Huang, K.,Hu, S.Q.,Jia, W.H.,Wang, S.H.,Brange, J.,Whittaker, J.,Arvan, P.,Katsoyannis, P.G.,Dodson, G.G. Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus To be Published, |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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