3ROV
Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, E, G, I... | Insulin | polymer | 21 | 2383.7 | 6 | UniProt (P01308) In PDB | Homo sapiens | Insulin A chain |
2 | B, D, F, H, J... | Insulin | polymer | 30 | 3462.0 | 6 | UniProt (P01308) Pfam (PF00049) In PDB | Homo sapiens | Insulin B chain |
3 | A, C, E, G, I... | PHENOL | non-polymer | 94.1 | 6 | Chemie (IPH) | |||
4 | B, D | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
5 | B, H | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
6 | water | water | 18.0 | 186 | Chemie (HOH) |
Sequence modifications
B, D, F, H, J, L: 1 - 30 (UniProt: P01308)
PDB | External Database | Details |
---|---|---|
Dal 20 | Gly 44 | engineered mutation |
Dal 23 | Gly 47 | engineered mutation |
Lys 28 | Pro 52 | engineered mutation |
Pro 29 | Lys 53 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 35074.2 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 766.4 | |
All* | Total formula weight | 35840.6 |