4NIB
Crystal structure of human insulin mutant B20 D-ala, B23 D-ala
Summary for 4NIB
Entry DOI | 10.2210/pdb4nib/pdb |
Descriptor | Insulin A chain, Insulin B chain (3 entities in total) |
Functional Keywords | hormone |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P01308 P01308 |
Total number of polymer chains | 2 |
Total formula weight | 5845.70 |
Authors | Menting, J.G.,Lawrence, M.C. (deposition date: 2013-11-05, release date: 2014-08-27, Last modification date: 2023-09-20) |
Primary citation | Menting, J.G.,Yang, Y.,Chan, S.J.,Phillips, N.B.,Smith, B.J.,Whittaker, J.,Wickramasinghe, N.P.,Whittaker, L.J.,Pandyarajan, V.,Wan, Z.L.,Yadav, S.P.,Carroll, J.M.,Strokes, N.,Roberts, C.T.,Ismail-Beigi, F.,Milewski, W.,Steiner, D.F.,Chauhan, V.S.,Ward, C.W.,Weiss, M.A.,Lawrence, M.C. Protective hinge in insulin opens to enable its receptor engagement. Proc.Natl.Acad.Sci.USA, 111:E3395-E3404, 2014 Cited by PubMed: 25092300DOI: 10.1073/pnas.1412897111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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