NMR structure of B25-(alpha, beta)-dehydro-phenylalanine insulin

Summary for 2MLI

DescriptorInsulin (2 entities in total)
Functional Keywordsinsulin analog, hormone
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5792.58
Yang, Y.,Weiss, M. (deposition date: 2014-02-27, release date: 2014-08-20, Last modification date: 2014-09-03)
Primary citation
Menting, J.G.,Yang, Y.,Chan, S.J.,Phillips, N.B.,Smith, B.J.,Whittaker, J.,Wickramasinghe, N.P.,Whittaker, L.J.,Pandyarajan, V.,Wan, Z.L.,Yadav, S.P.,Carroll, J.M.,Strokes, N.,Roberts, C.T.,Ismail-Beigi, F.,Milewski, W.,Steiner, D.F.,Chauhan, V.S.,Ward, C.W.,Weiss, M.A.,Lawrence, M.C.
Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111:E3395-E3404, 2014
PubMed: 25092300 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1412897111
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers38 3.0% 6.3%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload
PDB entries from 2020-10-21