3V1G

Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health

Summary for 3V1G

Related1TRZ 3V19
DescriptorInsulin, ZINC ION, PHENOL, ... (6 entities in total)
Functional Keywordszinc-binding site, long-acting insulin analog, receptor binding protein engineering, insulin fibrillation, hormone
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains4
Total molecular weight11895.68
Authors
Primary citation
Wan, Z.L.,Hua, Q.X.,Wickramasinghe, N.P.,Huang, K.,Petkova, A.T.,Hu, S.Q.,Phillips, N.B.,Yeh, I.J.,Whittake, J.,Ismail-Beigi, F.,Katsoyyannis, P.G.,Tycko, R.,Weiss, M.A.
Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published,
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.322261.1%2.2%6.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3v1g
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Molmil generated image of 3v1g
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Molmil generated image of 3v1g
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More Biological unit images

Molmil generated image of 3v1g
no rotation
Molmil generated image of 3v1g
rotated about x axis by 90°
Molmil generated image of 3v1g
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3v1g.pdb1.gz [57.01 KB])