3P2X

Insulin fibrillation is the Janus face of induced fit. A chiaral clamp stabilizes the native state at the expense of activity

Summary for 3P2X

Related3JSD 3P33
DescriptorInsulin, ZINC ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywordszinc-binding site, long-acting insulin analog, receptor binding protein engineering, global health, insulin fibrillation, hormone
Biological sourcehomo sapiens (Human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains4
Total molecular weight11959.19
Authors
Hua, Q.X.,Wan, Z.L.,Huang, K.,Hu, S.Q.,Phillip, N.F.,Jia, W.H.,Whittingham, J.,Dodson, G.G.,Katsoyannis, P.G.,Weiss, M.A. (deposition date: 2010-10-04, release date: 2011-11-23, Last modification date: 2014-10-15)
Primary citation
Hua, Q.X.,Wan, Z.L.,Huang, K.,Hu, S.Q.,Phillip, N.F.,Jia, W.H.,Whittingham, J.,Dodson, G.G.,Katsoyannis, P.G.,Weiss, M.A.
Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published,
Experimental method
X-RAY DIFFRACTION (2 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.3141903.3%7.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3p2x
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Molmil generated image of 3p2x
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Molmil generated image of 3p2x
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More Biological unit images

Molmil generated image of 3p2x
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Molmil generated image of 3p2x
rotated about x axis by 90°
Molmil generated image of 3p2x
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3p2x.pdb2.gz [28.83 KB])
Coordinate files for Biological unit (3p2x.pdb1.gz [28.47 KB])